Original Article

ACTIVITY OF 1-[(2-AMINOPHENYL)THIO]-1-PHENYL-2-NITROALKANE DERIVATIVES AGAINST HELICOBACTER PYKORI

  • Mehtap Gökçe
  • Berrin Özçelik
  • Yakut Akyon
  • Erdogan Berçin
  • Ningur Noyanalpan

Received Date: 25.03.2004 Accepted Date: 29.04.2004 Turk J Pharm Sci 2004;1(1):55-64

Abstract In this study, anti-Helicobacter pylori activity of previously synthesized 1-[(2-animophenyl)thio]-1-phenyl-2-nitroethane 1 and 1-[(2-aminophenyl]-1-phenyl-2-nitropropane 2 derivatives has been examined. Anti-Helicobacter pylori activity of these compounds was investigated in-vitro agar dilution method. Ampicillin and ofloxazin were used as references. According to the results anti-Helicobacter pylori activities of the compounds are not close to that of ampicillin and ofloxazin. However, compound 1b was found as having a comparable activity to reference compounds. Özet Bu çalismada sentezleri daha önceden yapilan 1-[(2-aminofenil)tiyo]-1-fenil-2-nitroetan 1 ve 1-[(2-aminofenil)tiyo]-1-fenil-2-nitropropan 2 türevlerinin anti-Helicobacter pylori aktivileri test edilmistir. Bilesiklerin anti-Helicobacter pylori aktiviteleri in-vitro agar dilution metodu ile arastirilmistir. Ampisilin veofloksazin referans bilesikler olarak kullanilmistir. Sonuçlara göre bilesiklerin anti-Helicobacter pylori aktivitesi ampisilin ve ofloksazine yakin degildir. Buna ragmen 1b bilesigi referans bilesiklerle kiyaslanabilir aktiviteye sahip bulunmustur.

Keywords: 1-[(2-aöinophenyl)thio]-1-phenyl-2-nitroalkane derivatives, ß-nitrostyrenes, anti-Helicobacter pylori activity