Short Communication

ANTIFUNGAL EFFECTS OF SOME OXADIAZOLE DERIVATIVES ON PATHOGENIC MOLDS

  • Zafer Asim KAPLANCIKLI
  • Mehlika Dilek ALTINTOP
  • Rasime DEMİREL

Received Date: 17.11.2011 Accepted Date: 12.01.2012 Turk J Pharm Sci 2013;10(1):145-150

Some oxadiazoIe derivatives were tested in vitro against Aspergillus parasiticus, Aspergillus flavııs, Aspergillus niger, Fusarium solani, Fusarium mondiforme and Stachybotrys chartarum. Ali compoımds showeâ the highest antifungal activity against S. chartarum. Among these compoımds (3a-j), compoımds 3a, 3c, 3d, 3e, 3i, 3j exhibited the same level of antifungal activity against ali tested mold species. Conıpounds 3a, 3c, 3d, 3e possess 4-methoxyphenoxymethyl moiety on oxadiazole ring, whereas compoımds 3i and 3j carrv 2-cyclohexylethyl moiety on oxadiazole ring.

Keywords: Oxadiazole, Antifungal activity, Aspergillus, Fusarium.