Original Article

Design and in-vitro characterization of orally disintegrating modified release tablets of naproxen sodium

10.4274/tjps.24445

  • Amjad Hussain
  • Maham Misbah
  • Nasir Abbas
  • Muhammad Irfan
  • Muhammad Sohail Arshad
  • Rahat Shamim
  • Nadeem Irfan Bukhari
  • Faisal Mahmood

Turk J Pharm Sci 0;0(0):0-0 [e-Pub]

INTRODUCTION:

The aim of of this study was to prepare orally disintegrating, slow release tablets of naproxen sodium for prompt onset and sustained action required in many types of acute pains.

METHODS:

Tablet formulations containing varying concentration of croscarmellose sodium (a super-disintegrant) and SoluplusĀ® (as release modifier), were prepared by wet granulation method using a single punch tablet machine. The prepared granules were evaluated for their bulk properties and the tablets were evaluated for hardness, disintegration time and drug release profiles.

RESULTS:

The results showed that the granules so prepared have good flow and compressional properties. The disintegration time (DT) of tablets <30 seconds was achieved by selecting an optimum concentration of croscormellose sodium. The drug release from the tablets was sustained for 2 hrs by incorporating suitable amount of soluplus.

DISCUSSION AND CONCLUSION:

This study depicts the use soluplus (a novel solubilizer) for the first time as release modifier of API from the tablets.

Keywords: rally disintegrating tablets, modified release tablets, naproxen sodium, soluplus