Introductıon:
Endometrial carcinoma is a typical gynecological malignant tumor which is occurring more frequently every year (EC). Obesity is a significant contributor to the development of EC and its prognosis. Lipid metabolism problem and malignant tumors have a long history of association. Elevated cholesterol levels are made possible by adenosine triphosphate binding cassette protein A1 (ABCA1) deficiency, which eventually promotes the survival of cancer cells. The relationship between ABCA1 and the occurrence, progression, and prognosis of EC is discussed in this article, as well as a potential mechanism.
Materıals and Methods:
The 45 endometrial adenocarcinoma patients included in this study were further divided into Grade 1 (15), Grade 2 (15), and Grade 3 (15) tumors. 29 endometrial tissues without a confirmed diagnosis of endometrial cancer made up the control group. ABCA1 gene expression was examined using realtime polymerase chain reaction (RT-PCR).
Results:
After the data were analyzed, it was found that the patient group's gene expressions were greater than the control group (p<0.05), and that there were differences in the patient group's grades (p<0.05). When ABCA1 expressions of grade groups and control groups were compared separately, statistically significant difference was found between grade 1, grade 2 and grade 3 and control group (p=0.0001).
Conclusıons:
According to the findings of our study, a key component in the growth of EC tumors is the increase in cholesterol production brought on by a reduction in ABCA1.
Keywords: ABCA1, endometrial cancer, cholesterol, ATP binding cassette protein, gene expression