Original Article

EVALUATION OF ANTI-INFLAMMATORY AND ANTINOCICEPTIVE ACTIVITIES OF HELICHRYSUM GAERTNER SPECIES (ASTERACEAE)

  • Esra KÜPELI
  • Alev TOSUN
  • Özlem BAHADIR

Received Date: 17.05.2006 Accepted Date: 02.08.2006 Turk J Pharm Sci 2006;3(3):141-149

Abstract The aqueous extracts obtainedfrom three Helichrysum species (Asteraceae) growing in Turkey, H. arenarium (L) Moench. subsp. aucheri (Boiss.) Davis & Kupicha, H. noeanum Boiss. and H. pilicatum DC. subsp.pilicatum, were evaluatedfor their in vivo anti-inflammatory activity using carrageenan-induced hind paw edema and antinociceptive activity using p-benzoquinone-induced abdominal constriction test. Aqueous extractsfrom H. arenarium and H.pilicatum subsp.pilicatum showed37.0 %, 30.4 % inhibition at 100 mg/kg doses and 31.2%, 28.3% at 200 mg/kg doses in p-benzoquinone-induced abdominal constriction test, respectively, without inducing any gastric damage. The aqueous extracts of all the plants didn’t show any anti-inflammatory activity in carrageenan-induced hind paw edema model at 50, 100 and 200 mg/kg doses. During the acute toxicity evaluation, neither death nor gastric bleeding was observedfor any oftheplant extracts.

Keywords: nti-inflammatory activity, Antinociceptive activity, H. arenarium (L.) Moench. subsp. aucheri (Boiss.) Davis & Kupicha, H. noeanum Boiss., and H. pilicatum DC. subsp. pilicatum, Asteraceae