In this study, adiponectin, protein carbonylation, TAC, TNF-a and IL-6 levels were measured in patients with hyperlipidemia and compared with healthy volunteers. Adiponectin, , TNF-a and IL-6 levels were analysed by ELISA method using kit. TAC and protein carbonylation levels were spectrophotometricaly measured. In total patient group, a significant differences was found in adiponectin and TAC levels compared with controls (p<0.05, p<0.01) Total patients were divided into three groups: hyperlipidemia, hyperlipidemia with coronary artery stenosis and coronary artery stenosis. Adiponectin levels were increased in hyperlipidemia with coronary artery stenosis group compared with control group (p<0.01). Protein carbonylation in hyperlipidemic group were higher than controls (p< 0.01). TAC levels were decreased in both hyperlipidemic group and hyperlipidemia with coronary artery stenosis group compared with control group (p< 0.05, p< 0.01). In hyperlipidemic patients, protein carbonylation was higher than hyperlipidemia with coronary artery stenosis patients (p<0.01). In conclusion, our study shows that oxidative stress is increased in hyperlipidemia. High adiponectin levels in hyperlipidemia with coronary artery stenosis may be due to protecting heart from oxidative damage.
Keywords: Adiponectin, Hyperlipidemia, OkMative stress, Coronary artery stenosis, Protein carbonylation, AntioAIdant.