Original Article

Myrtus communis Essential Oil for The Treatment of Hemorrhoids: A Randomized Double-Blind Double-Dummy Parallel-Group Comparative Study

  • Yunes PANAHI
  • Seyed Morteza MOUSAVI-NAYEENI
  • Amirhossein SAHEBKAR
  • Seyyed Ahmad FANAIE
  • Alireza RAHIMNIA
  • Fatemeh BEIRAGHDAR

Received Date: 09.03.2012 Accepted Date: 02.01.2013 Turk J Pharm Sci 2014;11(1):1-8

The aim of this study was to evaluate the efficacy of a topical lotion prepared from M. communis essential oil of in the alleviation of hemorrhoids symptoms, and compare its effects with those of anti-hemorrhoid ointment in a randomized double-blind double-dummy trial. A total of 106 patients with hemorrhoids symptoms were recruited and randomized to receive either M. communis lotion and placebo ointment (n=50; age: 36.2±10.8) or anti-hemorrhoid ointment (containing hydrocortisone, lidocaine, aluminium subacetate and zinc oxide) and placebo lotion (n=56; age: 40.6±11.1) for a period of two weeks. The severity and frequency of hemorrhoids symptoms were evaluated at baseline and at the end of trial. All evaluated symptoms (bleeding, permanent pain, pain during defecation, anal itching and irritation, heaviness and tenesmus) were significantly decreased by the end of trial in either of the study groups (p0.05). The results of this research provide the first clinical evidence on the efficacy of M. communis essential oil in the alleviation of hemorrhoids symptoms and further support the application of this plant as an anti-hemorrhoid agent in traditional medicine.

Keywords: Myrtle, Myrtaceae, Hemorrhoids, Randomized controlled trial, Human, Volatile oil.