Original Article

ISOLATION AND QUANTIFICATION OF AL ANT OL ACTONE/ISOAL ANT OL ACTONE FROM THE ROOTS OF INULA HELENIUM SUBSP. TURCORACEMOSA

  • Alper GÖKBULUT
  • Engin SARER

Received Date: 12.09.2012 Accepted Date: 07.11.2012 Turk J Pharm Sci 2013;10(3):447-452

Alantolactone/isoalantolactone, a mixture of isomeric sesquiterpene compounds, was isolated from the roots of Inula helenium L. subsp. turcoracemosa Grierson and its amount was quantified by RPHPLC. The structure of alan-tolactone/isoalantolactone was elucidated by using HPLC and 1NMR data. Alantolactone/isoalantolactone was fo-und in serious amount in the roots of the plant as 1.6338 ± 0.0198 % (w/w). The roots of Inula helenium subsp. tur-coracemosa growing in Turkey were found rich in this isomeric pair known to be strong antiproliferative and anti-microbial agent.

Keywords: Alantolactone/isoalantolactone, Inula helenium subsp. turcoracemosa, RP-HPLC