Original Article

SYNTHESIS, ANTIMICROBIAL SCREENING AND BETA LACTAMASE INHIBITORY ACTIVITY OF 3-(3-CHLORO-4-FLUOROPHENYLIMINO) INDOLIN-2-ON AND 5-CHLORO INDOLIN-2-ON DERI VATI VE S.

  • Subhas S. KARKI
  • Amol A. KULKARNI
  • Sreekanth THOTA
  • Sheetal NIKAM
  • Amit S. KAMBLE
  • Nagesh D. DHAWALE

Received Date: 09.09.2011 Accepted Date: 24.11.2011 Turk J Pharm Sci 2012;9(3):353-358

A series of various substituted 3-(3-chloro-4-fluorophenylimino)indolin-2-on and 5-chloro-3-(3- chloro-4-fluorophenylimino)indolin-2-on Mannich base derivatives (IIIa-f) were synthesized. All the synthesized compounds were characterized on the basis of UV, IR, and 1H NMR spectral data. These synthesized compounds were tested for their antibacterial activities against Gram +ve and Gram –ve bacteria and beta lactamase inhibitory activity which found as moderate to good for all synthesized compounds. The compound IIId was most active against all strains of bacteria as compared to synthetic compounds.

Keywords: Indolin-2-on, Antibacterial activitv, Beta lactamase inhibitors.