The synthesis and characterization of ruthenium complexes (Rul-Ru8) of the type [Ru(S)2(K)], (where S = 1,10-phenanthroline/ 2,2’-bipyridine and K = iinh, inhba, na, mitsz) are described. These ligands form bidentate octahedral ruthenium complexes. The title compounds were subjected to in vitro cytostatic activity measurements against the human cancer T-lymphocyte cell lines Molt 4/C8 and CEM, and the murine tumor leukemia cell line LI210. In vitro evaluation of these ruthenium compounds revealed cytotoxic activity from 0.84 to 119 ug/mL against CEM, 3.7 to 158 ug/mL against Molt and 15 to >200 ug/mL against LI 210 cell proliferation, depending the nature of the compound.
Keywords: Ruthenium complexes, Cytotoxicity, MLCT