Original Article

SYNTHESIS OF PLATINUM(II) COMPLEXES OF l-ARYL-3-(BENZIMIDAZOLE-2-YL)-PYRAZOLE-4-KETOXIMES AND STUDIES ON THEIR CYTOTOXIC EFFECTS

  • Kadriye BENKLİ
  • İsmail KAYAGİL
  • Zerrin İNCESU-SELLER
  • Gühergül ULUÇAM
  • Şeref DEMİRAYAK

Received Date: 14.11.2006 Accepted Date: 04.06.2007 Turk J Pharm Sci 2008;5(1):45-52

In this research, synthesis of some complexes in the presence of Pt(II) were studied. The structure of the compounds were elucidated by IR, 1H-NMR, Mass and Elemental Analyses. The cytotoxicity of Pt-complex was evaluated. The cellular responses through MTT method were measured in normal rat embryo fibroblast line F2408 and H-ras active-rat embryo fibroblast line 5RP7.

Keywords: Metal complexes, ketoximes, MTT