Original Article

ANTIMICROBIAL ACTIVITY OF 4-SUBSTITUTED- STYRYL-2-AZETIDINONES

  • Sema Tan
  • Vildan Adar Güner
  • Aysun Ergene

Received Date: 04.01.2005 Accepted Date: 12.05.2005 Turk J Pharm Sci 2005;2(1):11-15

Abstract In this study, antimicrobial activity of previously synthesized 1-(Substituted phenyl)-4-(substituted styryl)-2-azetidinones(3a-i) have been examined. All compounds have been tested against Gram(+) and Gram(-) bacteria and yeasts. It was found that activity is not significantly influenced by the substituents on the ring. Özet Bu çalismada, daha onceden sentezleri yapilan 1-(substitutefenil)-4-(substituestril)-2-azetidinonlarin (3a-i) antimikrobiyal aktiviteleri incelenmistir. Bütün bilesikler Gram (+) ve Gram (-) bakterilere ve mayaya karsi test edilmistir. Aktivite, halkadaki substituentlerden önemli derecede etkilenmedigi bulundu.

Keywords: 1-(substitutedphenyl)-4-(substituted styryl)2-azetidinones, antimicrobial activity.