Original Article

DELIVERY OF POORLY WATER SOLUBLE DRUG FROM SWELLABLE ELEMENTARY OSMOTIC PUMP AND EFFECT OF FORMULATION VARIABLES

  • Preeti PANDEY
  • Saurabh PANDEY

Received Date: 08.03.2012 Accepted Date: 05.07.2012 Turk J Pharm Sci 2013;10(2):221-236

An elementary osmotic pump (EOP) tablet for efficient delivery of poorly water-soluble drugs was designed and studied effect of composition factors. The designed system, called swellable elementary osmotic pump (SEOP). . Effect of composition factors on the release of drug from the SEOP tablets containing a poorly water-soluble drug, etodolac, have been studied. The release behaviour of drug from different formulations of this dosage form was studied at pH 6.8 for a period of 24 h. The formulations were compared based on four comparative parameters, namely, D24h (total release after 24 h), tL (lag time), RSQzero (R square of zero order equation) and D%zero (per-centage deviation from zero order kinetics). The drug release profile from osmotic devices showed that the type of polymer in the core formulation can markedly affect the drug release. Results showed that SEOP could be a no-vel way for the oral administration of poorly water soluble drug like etodolac.

Keywords: Controlled drug delivery, Etodolac, SEOP, Zero order release, Lag time.