The effects of a composite nanofiber wound dressing material consisting of a Poly Vinyl Alcohol and Poly Vinyl Pyrrolidone polymer mixture with a hemostatic agent doped with Ankaferd Blood Stopper on the healing of experimentally induced dermal wound in rats were examined. Rats were divided into 4 groups (n: 6). Histological material was examined on the tissues taken from the wound site, whereas Total Antioxidant Status, Total Oxidant Status, and Oxidative Stress Index analyses were performed on the blood samples taken from the cardia. The material that was produced had hydrophilic properties, and both the ABS doped and undopped forms of the material positively affected wound healing. In the histopathological examinations, macroscopic evaluations revealed a statistically significant difference between the groups in terms of wound diameter, reepithelization, and inflammation formation (p: 0.019). In parallel with wound healing and histological outcomes, TAS values increased in the ABS dopped groups, and TOS and OSI values decreased in the wound dressing groups (p<0.05). It was concluded that the ABS dopped dressing did not have a negative effect on wound healing, it accelerated healing, and it could be used effectively and safely to treat skin injuries. However, further studies are needed to evaluate the clinical and histopathological benefits and potential adverse effects of wound dressings produced by using ABS dopped polymers on wound healing.

Keywords: Ankaferd, Nanofiber, Wound, Rat, and Oxidative stress index.