Abstract Achillea species have been used for their anti-inflammatory, analgesic, spasmolytic, hemostatic, digestive and cholagogue effects in Turkish folk medicine. In order to evaluate their folkloric utilization, both antinociceptive and anti-inflammatory activities of five Achillea species including Achillea wilhelmsii C.Koch, A. setacea Waldst&Kit, A. vermicularis Trin., A. phrygia Boiss.&Bal. and A. sipikorensis Hausskn. et Borm. were investigated. For the antinociceptive activity, p-benzoquinoneinduced writhing test and for the anti-inflammatory activity, carrageenan-induced hind paw edema model in mice were employed. The ethanol extracts of A. wilhelmsii, A. setacea and A. vermicularis showed significant antinociceptive and anti-inflammatory activity at 500 mg/kg dose, per os, without inducing any apparent acute toxicity as well as gastric damage. A. phrygia was shown to possess only significant antinociceptive activity, on the other hand A. sipikorensis did not show any remarkable anti-inflammatory and antinociceptive activity. Özet Achillea türleri Türkiye’de halk arasinda, anti-enflamatuvar, analjezik, spazmolitik, hemostatik, dijestif ve kolagog etkilerinden dolayi kullanilmaktadir. Folklorik kullanimi degerlendirmek amaciyla, bes Achillea türünün “Achillea wilhelmsii C.Koch, A. setacea Waldst&Kit, A. vermicularis Trin., A. phrygia Boiss.&Bal. and A. sipikorensis Hausskn. et Borm.” antinonsiseptif ve anti-enflamatuvar aktiviteleri çalisildi. Antinosiseptif aktivite için p-benzokinon nedenli kivranma testi, anti-enflamatuvar aktivite için karragen-nedenli arka ayak ödemi testi uygulandi. A. wilhelmsii, A. setacea ve A. vermicularis’ten hazirlanan etanollü ekstre 500 mg/kg dozda herhangi bir akut toksisite ve gastrik hasar olusturmaksizin kuvvetli antinosiseptif ve anti-enflamatuvar aktivite gösterdi. A. phrygia sadece kuvvetli antinosiseptif aktivite gösterirken A.sipikorensis herhangi bir anti-enflamatuvar ve antinosiseptif aktivite göstermedi.

Keywords: Anti-inflammatory activity, Antinociceptive activity, Achillea phrygia, Achillea wilhelmsii, Achillea setacea, Achillea sipikorensis, Achillea vermicularis, Asteraceae