Short Communication

MOLECULAR ANALYSIS OF MYCOBACTERIAL DNA IN SOME CASES OF SARCOIDOSIS: CORRELATION WITH CLINICAL COURSE AND 10 YEARS’ OBSERVATION

  • Melahat KURTULUŞ ÜLKÜER
  • Özlem ÖZDEMİR KUMBASAR
  • Gökhan ÇELİK

Received Date: 16.04.2009 Accepted Date: 08.09.2009 Turk J Pharm Sci 2010;7(2):189-195

We present six patients with sarcoidosis whose transbronchial biopsy specimens had been investigated, the gene of immunogenic protein MPB64 for Mycobacterium tuberculosis by polymerase chain reaction analysis. M. tuberculosis DNA was detected in three of them by PCR. We followed patients with sarcoidosis for ten years. We discussed tuberculin test results and clinical course of M. tuberculosis positive and negative patients with polymerase chain reaction, we cannot make a conclusion about a relationship between clinical course and mycobacterial DNA positivity.

Keywords: Sarcoidosis, M. tuberculosis, Polymerase chain reaction, Clinical course