Original Article

Synthesis and Antimicrobial Activity of Some Piperazine Dithiocarbamate Derivatives

  • Usama ABU MOHSEN

Received Date: 16.03.2014 Accepted Date: 15.05.2014 Turk J Pharm Sci 2014;11(3):347-354

Nine new dithiocarbamic acid ester derivatives, including thiazole moiety, were synthesized and investigated for their antimicrobial activity. The structures of the obtained final compounds (6a-i) were confirmed by spectral data (IR, 1H-NMR, 13C-NMR and MS). The antimicrobial activity of the compounds was determined (6a-i) by using the microbroth dilution method. Antimicrobial activity results revealed that synthesized compounds exhibited moderate antimicrobial activity against to E. faecalis (ATCC 51922) and P. aeruginosa (ATCC 27853).

Keywords: Thiazole, Dithiocarbamate, Antimicrobial activity