The aim of this study was to prepare a formulation would be more efficient and better patient compliance and alternative to topical preparations currently used in the market. For these purpose inclusion complexes were pre-pared with two different cyclodextrins. Aqueous solubility, X-ray diffraction analysis and DSC analysis were carried out on the inclusion complexes. Besides the two different semisolid vehicles were formed by using inclusion complexes that were selected. In vitro drug release from formulations prepared was investigated using Franz dif-fusion cells in pH 6.0 buffer solution. Formulations prepared with inclusion complex exhibited significantly higher drug release when compared to the other formulations contained free drug and commercial preparations. The diffusion coefficient, permeability coefficient and vehicle/membrane partition coefficient were calculated using the data obtained from statistical analysis. All result taking accounts, hydrogel type formulations prepared with beta-cyclodextrin inclusion complex were seen as more appropriate vehicle for clinical trial to acne vulgaris pati-ents.

Keywords: all-trans Retinoic acid, Incliision complexes, Beta-cvclodextrin, 2-Hydroxypropyl beta-cvclodextrin (Encapcin ®), In vitro driig release.