Original Article

The Effects of Eryngium campestre Extracts on Glutathione-S-Transferase, Glutathione Peroxidase and Catalase Enzyme Activities

  • Merve G. GÜNEŞ
  • Belgin S. İŞGÖR
  • Yasemin G. İŞGÖR
  • Fatmagül GEVEN
  • Özlem YILDIRIM

Received Date: 06.03.2014 Accepted Date: 08.05.2014 Turk J Pharm Sci 2014;11(3):339-346

Eryngium campestre L. (Apiaceae) are known in Turkish folk medicine as ‘Bogadikeni’ and wildly distributed in all parts of Turkey. Infusion of different parts of this species are well known as diuretic, appetizer and stimulant. In the present study, methanol extracts from flowers and leaves of E. campestre were evaluated for their potential medicinal value in terms of biological targets participate in antioxidant defense such as glutathione-S-transferase (GST), glutathione peroxidase (GPx) and catalase (CAT). Results obtained show that the methanol extract of flowers were found to have higher amount of phenolic and flavonoid contents than the leaves. The evaluation of extracts against biological target revealed that, the maximum GST enzymes inhibition activities was observed with methanol extract from flowers of E. campestre with IC50 value of 363 ng/mL. In this study, none of the extracts evaluated were shown any reasonable GPx and CAT inhibition.

Keywords: Eryngium campestre, Glutathione-S-transferase, Glutathione peroxidase, Catalase