E-ISSN: 2148-6247
ANTIBACTERIAL AND CYTOTOXIC ACTIVITY OF MEYNA SPINOSA ROXB. STEM
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Short Communication
VOLUME: 9 ISSUE: 2
P: 225-230
August 2012

ANTIBACTERIAL AND CYTOTOXIC ACTIVITY OF MEYNA SPINOSA ROXB. STEM

Turk J Pharm Sci 2012;9(2):225-230
Raihana PERVIN 1
Farah SABRIN 2
Md. Morsaline BILLAH 1
M. Didarul ISLAM 1
Jamal ELMEZUGHI 3
Jamil A. SHILPI 4
1. Khulna University, Biotechnology And Genetic Engineering Discipline, Khulna 9208, Bangladesh
2. Mawlana Bhashani Science And Technology University, Department Of Biotechnology And Genetic Engineering, Tangail 1902, Bangladesh
3. Al Fatah University, Department Ofpharmacy, Tripoli, Lıbya
4. Khulna University, Pharmacy Discipline, Khulna 9208, Bangladesh
No information available.
No information available
Received Date: 10.02.2011
Accepted Date: 24.03.2011
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ABSTRACT

Meyim spinosa Roxb., a medicinai plant enjoys it itse in the traditional medicine in Bangladesh for the treatment of a number of ailnıents. The present stıtdy was undertaken to investigate the antibaeterial and cvtotoxic activitv of the ethanol extract of Mevna spinosa stem. Antibaeterial activity was investigated against Staphylococcus aureus, Streptococcus pvogenes, Escherichia coli and Shigella dysenteriae by disc diffıtsion and broth maerodilution assay. İn disk diffusion assav, the extract inhibited ali the microorganisms except E. coli. Minimum inhibitorv concentration (MIC§ of the extract w as 1000 ptg/ml for S. aureus, S. pvogenes and E. coli, whereas 500 jug/mL for S. dysenteriae. For cytotoxicity test, the extract w as subjected to brine shrimp lethality bioassav. The LD50 of M. spinosa stem extract was found to be 40 pg/mL. Findings of the stıtdy jııstify the itse of the plant in traditional medicine and suggests for further investigation.

Keywords:
Meyna spinosa, Antimikrobiyal aktivite, Brine shrimp letalite.