ABSTRACT

Venlafaxine belongs to a group of Antidepressant with a novel chemical structure. A rapid, specific reversed - phase HPLC method has been developed for assaying Venlafaxine in pharmaceutical dosage forms involving an isocratic elution in CI8 column using a mobile phase composition of phosphate buffer (pH: 3.6)-acetonitril (60: 40, v/v). The flow rate was 1 mL/min at 225 nm. For separation of impurities composition of mobile phase was phosphate buffer pH:5 - acetonitril - methanol (80:13:7, v/v/v). Also, simple, rapid and precise an UV spectrophotometric method was developed for dissolution studies. All the validation parameters were within the acceptance range. The proposed methods are sensitive, accurate, reproducible and useful for the routine determination of venlafaxine in tablets.