Cytotoxicity Evaluation of Some Phenolic Compounds in V79 Cells
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Original Article
P: 299-304
December 2015

Cytotoxicity Evaluation of Some Phenolic Compounds in V79 Cells

Turk J Pharm Sci 2015;12(3):299-304
1. Hacettepe University, Faculty Of Pharmacy, Department Of Pharmaceutical Toxicology, 06100 Ankara, Turkey\R\N
2. Hacettepe University, Faculty Of Pharmacy, Department Of Pharmacognosy 06100 Ankara, Turkey\R\N
No information available.
No information available
Received Date: 25.12.2014
Accepted Date: 28.05.2015
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ABSTRACT

Phenolic compounds play an important role on the growth and reproduction of plants and also exhibit a wide range of pharmacological activities such as anti-allergic, anti-artherogenic, anti-inflammatory and anticancer. But the data about toxicity of many phenolics are lacking and limited. The aim of this study was to evaluate the cytotoxic effects of five different commonly used phenolic compounds (galangin, limonene, naringin, puerarin and ursolic acid) which are widely used because of their health protecting effects by neutral red uptake (NRU) assay in Chinese hamster fibroblast cell line (V79). It is found that all of the studied phenolics decreased the cell viability of V79 cells in a dose dependent manner. The IC50 values of galangin, limonene, naringin, puerarin and ursolic acid were found to be 104.36 pM, 10574 pM, 1976.4 pM, 51.71 pM and 92.94 pM, respectively.

Keywords:
Galangin, Limonene, Naringin, Puerarin, Ursolic acid, Neutral red uptake assay