DIHYDROISOCOUMARIN DERIVATIVES ISOLATED FROM THE ROOTS OF SCORZONERA LATIFOLIA
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Original Article
P: 205-212
December 2010

DIHYDROISOCOUMARIN DERIVATIVES ISOLATED FROM THE ROOTS OF SCORZONERA LATIFOLIA

Turk J Pharm Sci 2010;7(3):205-212
1. Ankara University, Faculty Of Pharmacy, Department Of Pharmacognosy, 06100, Ankara, Turkey
2. Università Degli Studi Di Padova, Dipartimento Di Scienze Farmaceutiche, Natural Product Lab (Npl),Via Marzolo, 5 - 35100 Padova, Italy
No information available.
No information available
Received Date: 11.06.2009
Accepted Date: 04.02.2010
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ABSTRACT

Scorzonera latifolia (Fisch. & Mey.) DC. is a perennial herb that grows in central and eastern region of Anatolia, Turkey. A traditional mastic named yakı sakızı has been prepared from the roots of this plant and used as an analgesic in Turkish folk medicine. In this study, the methanolic extract obtained from the roots of S. latifolia were investigated for the chemical composition. Two dihydroisocoumarin derivatives were isolated from the roots. The compounds were identified as (±) hydrangenol and (-)-scorzotomentosin 4'-0-β-glucopyranoside. The structures were determined using spectroscopic methods (1H-NMR, 13C-NMR, HMBC, HSQC, COSY, TOCSY, NOESY, DEPT) and chemical correlations with known compounds that have been described in the literature.