Evaluation of Anticancer and Antioxidant Activities of Coffee Stem Parasite Extract <i>(Scurrula Ferruginea (Roxb. Ex Jack) Danser)</i> and in Silico Studies of its Isolate
PDF
Cite
Share
Request
Original Article
P: 0-0

Evaluation of Anticancer and Antioxidant Activities of Coffee Stem Parasite Extract (Scurrula Ferruginea (Roxb. Ex Jack) Danser) and in Silico Studies of its Isolate

Turk J Pharm Sci 0;0(0):0-0
1. Medan State University, Chemistry Study Program, Faculty of Mathematics and Natural Sciences
2. National Taiwan University of Science and Technology, Department of Chemical Engineering, Taipei, Taiwan
No information available.
No information available
Received Date: 04.08.2023
Accepted Date: 17.12.2023
PDF
Cite
Share
Request

ABSTRACT

This research aims to examine the potential of the parasite Scurrula ferruginea (Roxb. Ex Jack) Danser on coffee stems as a natural anticancer. In-silico and in-vitro studies have been carried out on coffee stem parasite extracts to analyze compounds that have the potential to act as HER2 inhibitors, the antioxidant activity of the extract, and the extract's ability to act as an anticancer agent against HeLa and MCF-7 cells. The research results show that several components in coffee stem parasite extract, including flavonoids and fatty acids, have the potential to act as HER2 inhibitors. The coffee stem parasite extract has strong antioxidant activity with IC50 of 59.736 ppm but is inactive against cancer cells. Characterization using gas chromatography-mass spectrometry showed the presence of bis (2-Ethylhexyl) phthalate (C24H38O4) in coffee stem parasite extract, which is toxic as an anticancer drug.

Keywords: anticancer, antioxidant, bis (2-Ethylhexyl) phthalate, coffee parasite, HER2 inhibitors.

2024 ©️ Galenos Publishing House