Evaluation of the Genotoxic Effects of Patients Undergoing Hyperbaric Oxygen (HBO) Therapy

Turk J Pharm Sci 2014;11(2):203-208

1. Ankara University, Faculty Of Pharmacy, Department Of Pharmaceutical Toxicology, 06100 Tandogan - Ankara, Turkey

2. Gülhane Military Medical Academy, Underwater And Hyperbaric Medicine, Ankara, Turkey

3. Gülhane Military Medical Academy, Haydarpasa Hospital, Underwater And Hyperbaric Medicine Service, 81010 Kadiköy-Istanbul, Turkey

4. Gölcük Military Hospital, Izmit, Turkey

5. Ankara University, Faculty Of Pharmacy, Department Of Pharmaceutical Toxicology, 06100 Tandogan - Ankara, Turkey,

6. Yeditepe University, Faculty Of Pharmacy, Department Of Toxicology, 26 Agustos Yerle§İmi, 34755 Kayi§Dagi, Atasehir-İstanbul, Turkey

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Received Date: 06.01.2014

Accepted Date: 06.03.2014

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ABSTRACT

Hyperbaric oxygen (HBO) therapy is successfully applied for a wide variety of diseases. However, recent studies in humans undergoing hyperbaric oxygen (HBO) therapy have revealed that HBO is able to induce genotoxic effects especially in lymphocytes while the biological significance of tlıis outcome is stili not clear. HBO mediated genotoxicity in lymphocytes has been determined by using the in vitro Cytokinesis Block Micronucleus (MN) test in patients undergoing HBO therapy. Blood samples were obtained from 100 voluntary patients and were drawn by venipuncture before and immediately after the fırst session of HBO treatment. MN frequencies were signifıcantly increased after the first session of HBO treatment. According to the MN test results, it is observed that HBO treatment can increase the clastogenic effects.

Keywords:

Hyperbaric oxygen therapy, Genotoxicity, Micronucleus test