Formulation and Evaluation of Butenafine Hydrochloride Incorporated Solid Lipid Nanoparticles from Novel Excipients for the Treatment of Superficial Fungal Infection
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Original Article
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Formulation and Evaluation of Butenafine Hydrochloride Incorporated Solid Lipid Nanoparticles from Novel Excipients for the Treatment of Superficial Fungal Infection

Turk J Pharm Sci 0;0(0):0-0
1. Dr. Kolpe Institute of Pharmacy, Kolpewadi-423602, Tal. Kopergaon, Dist. Ahmednagar, Maharashtra, India
2. MET’s Institute of Pharmacy, Adgaon, Nashik-422003, Maharashtra, India.
3. Glenmark Pharmaceuticals Ltd., Sinnar-422113, Nashik, Maharashtra, India
No information available.
No information available
Received Date: 19.06.2023
Accepted Date: 28.08.2023
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ABSTRACT

Objectives:

The objective of present research was to develop natural excipients based solid lipid nanoparticles (SLN) of butenafine hydrochloride (BUTE) by using modified solvent emulsification technique and to evaluate the competence of aloe vera nanolipidgel in enhancing the penetration of BUTE.

Materials and Methods:

The BUTE-SLNs were prepared by 23 factorial design to correlate the effect of formulation components on the BUTE-SLN. Particle size, polydispersity index, zeta potential, entrapment performance, and drug loading were assessed in the formed SLNs. The average particle size and polydispersity index were observed to be 261.25±2.38 nm and 0.268±0.01 respectively. Fabricated BUTE-SLN was evaluated for TEM, FTIR, DSC and XRD study and revealed the encapsulation of butenafine hydrochloride in lipid in amorphous state. BUTE-SLN based aloe vera gel was formulated and evaluated comparatively with the marketed product with respect to primary skin irritation, hydration, skin permeation and antifungal activity.

Result:

The BUTE-SLN promisingly showed no irritation, higher hydrating potential, slow and sustained release and enhanced antifungal activity. With an aim to target the deeper skin strata, to minimize the side effects of drugs and symptomatic effects of fungal infection and to shorten duration of therapy BUTE-SLN has been successfully prepared.

Conclusion:

BUTE-SLN gel offer improved topical delivery of BUTE with significantly higher compatibility and the antifungal activity as compared to marketed formulation.

Keywords: Modified solvent emulsification technique, factorial design, butenafine, aloe vera gel, Natural origin lipid and surfactant, In Vitro antifungal activity.

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