LONGITUDINAL EVALUATION OF DEVELOPMENTAL PROTEIN MALNUTRITION RESEMBLING MARASMIC-KWASHIORKOR CONDITION IN WISTAR RATS
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LONGITUDINAL EVALUATION OF DEVELOPMENTAL PROTEIN MALNUTRITION RESEMBLING MARASMIC-KWASHIORKOR CONDITION IN WISTAR RATS

1. Nitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Department of Nitte University Centre for Animal Research and Experimentation (NUCARE), Paneer campus, Deralakatte, Mangaluru, Karnataka State – 575018, India
2. Nitte (Deemed to be University), K. S. Hegde Medical Academy, Nitte University Center for Stem Cell Research and Regenerative Medicine, Deralakatte-575018, Mangaluru, India
3. Nitte (Deemed to be University), K. S. Hegde Medical Academy Department of Microbiology, Deralakatte, Mangaluru 575018, India
No information available.
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Received Date: 19.08.2023
Accepted Date: 23.12.2023
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ABSTRACT

Objectives:

Protein malnutrition (PMN) is a significant public health concern that aggravates pathological states. Impact of early malnutrition on metabolism needs extensive evaluation. Current models employ shortterm diet-restriction, and are neither ethically right nor clinically relevant. This study outlines the development of a PMN rat model to evaluate the effects of low protein diet (LPD) on physiological, hematological, biochemical, and histological changes affected by malnourishment from post-weaning to 40th week.

Materials and methods:

The PMN model was developed in Wistar rats (post weaning) by assigning randomized animals to patented LPD (10% protein) and the control group to normal diet (18% protein).

Results:

LPD-induced PMN showed stunted growth, altered biochemical and hematological markers, and significantly affected hepatic histology. Long-term study was conducted to analyze the pattern of developmental PMN and its stabilization over time.

Conclusion:

The developed PMN rat model imitates the clinical condition and is confirmed as a stable, reproducible, and reliable model for short- and long-term studies. Its clinical relevance opens the avenue for research in treatment, drug development, molecular interactions, and disease model development.

Keywords:
Animal model
Biochemical parameters
Low protein diet
Marasmic- kwashiorkor
Protein malnutrition
Rats