LONGITUDINAL EVALUATION OF DEVELOPMENTAL PROTEIN MALNUTRITION RESEMBLING MARASMIC-KWASHIORKOR CONDITION IN WISTAR RATS
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Original Article
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LONGITUDINAL EVALUATION OF DEVELOPMENTAL PROTEIN MALNUTRITION RESEMBLING MARASMIC-KWASHIORKOR CONDITION IN WISTAR RATS

Turk J Pharm Sci 0;0(0):0-0
1. Nitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Department of Nitte University Centre for Animal Research and Experimentation (NUCARE), Paneer campus, Deralakatte, Mangaluru, Karnataka State – 575018, India
2. Nitte (Deemed to be University), K. S. Hegde Medical Academy, Nitte University Center for Stem Cell Research and Regenerative Medicine, Deralakatte-575018, Mangaluru, India
3. Nitte (Deemed to be University), K. S. Hegde Medical Academy Department of Microbiology, Deralakatte, Mangaluru 575018, India
No information available.
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Received Date: 19.08.2023
Accepted Date: 23.12.2023
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ABSTRACT

Objectives:

Protein malnutrition (PMN) is a significant public health concern that aggravates pathological states. Impact of early malnutrition on metabolism needs extensive evaluation. Current models employ shortterm diet-restriction, and are neither ethically right nor clinically relevant. This study outlines the development of a PMN rat model to evaluate the effects of low protein diet (LPD) on physiological, hematological, biochemical, and histological changes affected by malnourishment from post-weaning to 40th week.

Materials and methods:

The PMN model was developed in Wistar rats (post weaning) by assigning randomized animals to patented LPD (10% protein) and the control group to normal diet (18% protein).

Results:

LPD-induced PMN showed stunted growth, altered biochemical and hematological markers, and significantly affected hepatic histology. Long-term study was conducted to analyze the pattern of developmental PMN and its stabilization over time.

Conclusion:

The developed PMN rat model imitates the clinical condition and is confirmed as a stable, reproducible, and reliable model for short- and long-term studies. Its clinical relevance opens the avenue for research in treatment, drug development, molecular interactions, and disease model development.

Keywords: Animal model, Biochemical parameters, Low protein diet, Marasmic- kwashiorkor, Protein malnutrition, Rats

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