MOLECULAR ANALYSIS OF MYCOBACTERIAL DNA IN SOME CASES OF SARCOIDOSIS: CORRELATION WITH CLINICAL COURSE AND 10 YEARS’ OBSERVATION
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Short Communication
P: 189-195
August 2010

MOLECULAR ANALYSIS OF MYCOBACTERIAL DNA IN SOME CASES OF SARCOIDOSIS: CORRELATION WITH CLINICAL COURSE AND 10 YEARS’ OBSERVATION

Turk J Pharm Sci 2010;7(2):189-195
1. University Of Gazi, Faculty Of Pharmacy, Department Of Pharmaceutical Microbiology, 06330 Etiler-Ankara, Turkey
2. University Of Ankara, Faculty Of Medicine, Department Of Pulmonary Diseases, 06100 Sihhiye-Ankara, Turkey
No information available.
No information available
Received Date: 16.04.2009
Accepted Date: 08.09.2009
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ABSTRACT

We present six patients with sarcoidosis whose transbronchial biopsy specimens had been investigated, the gene of immunogenic protein MPB64 for Mycobacterium tuberculosis by polymerase chain reaction analysis. M. tuberculosis DNA was detected in three of them by PCR. We followed patients with sarcoidosis for ten years. We discussed tuberculin test results and clinical course of M. tuberculosis positive and negative patients with polymerase chain reaction, we cannot make a conclusion about a relationship between clinical course and mycobacterial DNA positivity.

Keywords:
Sarcoidosis, M. tuberculosis, Polymerase chain reaction, Clinical course