E-ISSN: 2148-6247
Nootropic Activity of Vitis vinifera Juice in Normal and Memory- Impaired Mice Using Spatial Learning and Recognition Memory Paradigms
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Original Article
VOLUME: 12 ISSUE: 3
P: 327-336
December 2015

Nootropic Activity of Vitis vinifera Juice in Normal and Memory- Impaired Mice Using Spatial Learning and Recognition Memory Paradigms

Turk J Pharm Sci 2015;12(3):327-336
Muhammad ASLAM
Nuzhat SULTANA
1. University Of Karachi, Faculty Of Pharmacy, Department Of Pharmacology, 75270, Pakıstan
No information available.
No information available
Received Date: 12.02.2015
Accepted Date: 07.05.2015
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ABSTRACT

Vitisvinifera Linn. (Grape) contains a variety of bioactive components including polyphenols. Flavonoids are the major phenolic compounds (65–76%) in grapes. Grape phenolics possess several health promoting properties due to their antioxidant potential. It is thought that antioxidants have memory-enhancing potential. Therefore, in this study, we evaluated the nootropic activity of the Vitis vinifera fruit juice in normal and memory-impaired mice using the Morris water maze model and object recognition test. In the Morris water maze model, there was a significant decrease in escape latency (EL) and a significant increase in time spent in the target quadrant (TSTQ) as compared with normal control and memory-impaired mice (P)

Keywords:
Vitis vinifera, Memory-enhancing, Dementia, Nootropic, Morris water maze, Object recognition test