E-ISSN: 2148-6247
Preparation and Evaluation of Chitosan Succinate Pellets Using Extrusion-Spheronization Technology: Processing and <i>In Vitro</i> Characterization
PDF
Cite
Share
Request
Original Article
VOLUME: 13 ISSUE: 2
P: 189-200
August 2016

Preparation and Evaluation of Chitosan Succinate Pellets Using Extrusion-Spheronization Technology: Processing and In Vitro Characterization

Turk J Pharm Sci 2016;13(2):189-200
Dasari Subramaniyam KARUNA 1
Ubaidulla UDHUMANSHA 1
Grace RATHNAM 1
Mani GANESH 2
Hyun Tae JANG 2
1. C.L. Baid Metha College Of Pharmacy, Department Of Pharmaceutics, Chennai, Indıa
2. Hanseo University, Department Of Chemical Engineering, Seosan-Si 356 706,South Korea
No information available.
No information available
Received Date: 26.11.2015
Accepted Date: 18.02.2016
PDF
Cite
Share
Request

ABSTRACT

The study is aimed to investigate a novel approach for the preparation of multiparticulate drug delivery system using chitosan succinate a chitosan derivatives polymer. Herein the chitosan succinate multiparticulate pellets ent-rapped diclofenac sodium was prepared by extrusion and spheronization technique. FTIR results revealed that there were no interactions between the drug and polymer. The prepared pellets were with good spherical geo-metry and 1.02±0.40 mm as their mean diameter. Chitosan succinate showed pH dependent release profiles for the entrapped diclofenac sodium. Maximum drug release was observed at pH 7.4, whereas no drug release was observed at pH 1.2. The optimized formulation followed Higuchi kinetics while drug release mechanism was found to be anomalous type i.e controlled by diffusion through swollen matrix. It can be concluded from these results that new pharmaceutical carrier is capable of sustained release in oral drug delivery system.

Keywords:
Chitosan succinate pellets, pH sensitive drug release, Chitosan, Sustained release, Extrusionspheronization.