ABSTRACT

Two simple, rapid and selective spectrophotometric methods are described for the determination of domperidone (DOM) in pure drug and in pharmaceuticals. The methods are based on the formation of charge-transfer complex between DOM as n-donor and n-acceptors like 2, 3-dichloro-5,6-dicyano-l,4- benzoquinone (DDQ) in method A or p-chloranilic acid (p-CA) in method B. The products exhibit absorption maxima at 590 and 520 nm in acetone for method A and method B, respectively. Under the optimum reaction conditions, linear relationships with good correlation coefficients (0.998 in method A and 0.999 in method B) were found between the absorbance and the concentration of DOM in the ranges of 5-80 and 20-320 pig/mL in method A and method B, respectively. The apparent molar absorptivity values are calculated to be 4.88 x 103 and 1.14 x 103 , L/mol/cmJor method A and method B, respectively, with corresponding Sandell sensitivity values of 0.021 and 0.017 pig/cm2 . The limit of detection (LOD) values are found to be 0.28 and 1.19 ng/mL for method A and method B, respectively, with corresponding limit of quantification (LOQ) values of 0.86 and 3.59 pig/mL. The stoichiometry of the reaction was found to be 1:1 in both the cases. The proposed methods were applied successfully for the determination of DOM in tablets with good accuracy and precision. The results obtained by the proposed methods were compared favorably with those of the reference method.