E-ISSN: 2148-6247
Simultaneous Quantification of Metolazone and Ramiprilin Their Combined Dosage Form by First Order Derivative Spectroscopic Method
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Original Article
VOLUME: 12 ISSUE: 2
P: 169-176
August 2015

Simultaneous Quantification of Metolazone and Ramiprilin Their Combined Dosage Form by First Order Derivative Spectroscopic Method

Turk J Pharm Sci 2015;12(2):169-176
Pratik R. MODI 1
Usmangani K. CHHALOTIYA 1
Dimal A. SHAH 1
Falgun A. MEHTA 1
Kashyap K. BHATT 2
1. Indukaka Ipcowala College Of Pharmacy, Department Of Pharmaceuticalchemistry And Analysis,Beyond Gıdc, P.B. No. 53, Vitthal Udyognagar- 388 121,Gujarat, Indıa
2. Indukaka Ipcowala College Of Pharmacy, Department Of Pharmaceutical Chemistry And Analysis,Beyond Gıdc, P.B. No. 53, Vitthal Udyognagar- 388 121,Gujarat, Indıa
No information available.
No information available
Received Date: 13.03.2014
Accepted Date: 26.02.2015
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ABSTRACT

A simple, accurate and precise first order derivative spectrophotometric method was developed for simultaneous determination of Metolazone (MET) and Ramipril (RAM) in their combined pharmaceutical dosage form. MET and RAM were quantified using first derivative responses at 285nm and 212nm respectively. Methanol was taken as a common solvent. The calibration curve were linear in the concentration range of 5-25 μg/mL for MET and 8-24 μg/mL for RAM. The method was validated and found to be accurate and precise. Developed method was successfully applied for the estimation of MET and RAM in their combined dosage form.

Keywords:
Metolazone (MET), Ramipril (RAM), First order derivative, Validation.