E-ISSN: 2148-6247
STUDIES ON SOME NEW PYRAZOLO[3,4-c]PYRIDINE DERIVATIVES AS ANTIMICROBIAL AGENTS
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Original Article
VOLUME: 6 ISSUE: 2
P: 63-72
August 2009

STUDIES ON SOME NEW PYRAZOLO[3,4-c]PYRIDINE DERIVATIVES AS ANTIMICROBIAL AGENTS

Turk J Pharm Sci 2009;6(2):63-72
Gülhan TURAN-ZITOUNI 1
Ahmet ÖZDEMİR 1
Zafer Asım KAPLANCIKLI 1
Adile ÇEVİKBAŞ 2
Burçak GÜRBÜZ 2
Ümran S. GÜRER 2
1. Anadolu University, Faculty Of Pharmacy, Department Of Pharmaceutical Chemistry, 26470 Eskisehir, Turkey
2. Marmara University, Faculty Of Pharmacy, Department Of Pharmaceutical Microbiology, Haydarpasa-Istanbul, Turkey
No information available.
No information available
Received Date: 16.05.2008
Accepted Date: 03.12.2008
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ABSTRACT

The increasing clinical importance of drug-resistant bacterial and fungal pathogens has lent additional urgency to microbiological research and novel antimicrobial compounds development. For this aim, a series of N-[(Benzhdryl) 7 (1-phenylethyl)]-2-pyrazolo[3,4-c]pyridin-l-yl acetamide derivatives (3a-m) were synthesized by reacting 2-chloro-N-(benzhydiyl)acetamide (1a) / 2-chloro-N-1-phenylethyl) acetamide (1b) andpyrazolo[3,4-c]pyridine derivatives (2). The chemical structures of the compounds were elucidated by elemental analyses, IR, 1H-NMR, FAB+-MS spectral data. Their antimicrobial activities against E. coli (ATCC 11229), S. aureus (ATCC 6538), B. cereus (ATCC 11778), P. mirabilis (ATCC 14153), P. aeruginosa (ATCC 1539), K. pneumoniae (ATCC 4352), C. albicans (ATCC 26555), C. guilliermondii (KUEN 998), C. pseudotropicalis (kefyr) (KUEN1014), and C. krusei (ATCC 6258) were investigated. The results showed that some of the compounds have slight activity against B. cereus and S. aureus. Whereas, the same compounds did not show any significant antifimgal activity against Candida species.

Keywords:
Pyrazolo[3, 4-c]pyridine derivatives, Acetamide, Antimicrobial activity