E-ISSN: 2148-6247
SYNTHESIS AND ANTIMICROBIAL ACTIVITY EVALUATION OF NEW HYDRAZIDE DERIVATIVES
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Original Article
VOLUME: 8 ISSUE: 3
P: 199-206
December 2011

SYNTHESIS AND ANTIMICROBIAL ACTIVITY EVALUATION OF NEW HYDRAZIDE DERIVATIVES

Turk J Pharm Sci 2011;8(3):199-206
Gülhan TURAN ZITOUNI 1
Ahmet ÖZDEMİR 1
Zafer Asım KAPLANCIKLI 1
Gilbert REVIAL 2
Fatih DEMİRCİ 3
1. Anadolu University, Faculty Of Pharmacy, Department Of Pharmaceutical Chemistry, 26470 Eskisehir, Turkey
2. Laboratoire De Transformations Chimiques Et Pharmaceutiques, Umr-Cnrs 7084, Cnam, 2 Rue Conte', 75003 Paris, France
3. Anadolu University, Faculty Of Pharmacy, Department Of Pharmacognosy, 26470 Eskisehir, Turkey
No information available.
No information available
Received Date: 11.08.2010
Accepted Date: 03.11.2010
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ABSTRACT

The enhancement of bacterial resistance of pathogens to currently available antibiotics constitutes a serious public health threat. Therefore, intensive efforts are underway worldwide to develop new antimicrobial agents. To identify compounds with a potent antimicrobial profile, we designed and synthesized some hydrazide derivatives la-e. The chemical structures of the compounds were elucidated by elemental analyses, IR, 1H-NMR, I3C-NMR and FAB+-MS spectral data. Their antimicrobial activities against to E. coli (NRRL B-3008), Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 27853), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (ATCC 13311), Methicillin-resistant Staphylococcus aureus (MRSA) (clinic isolate), Candida albicans (NRRL Y-12983) and Candida parapsilosis (NRRL Y-12696) were investigated. The results showed that all of the tested compounds were inactive against the test organism.

Keywords:
Hydrazide, 5, 6, 7, 8-tetrahydro-2-naphthol, Aldehydes, Antimicrobial activity