ABSTRACT

A series of 1,3,5-trisubstituted-2-oxindole derivatives have been synthesized by reaction of 2,3-dihydro-2,3-dioxindol , l-benzyl-2,3-dihydro-2,3-dioxindole and an appropriate benzoyl hydrazide. Structures of these compounds were established by IR, !H NMR, I3C NMR, Mass spectroscopy. All the compounds were evaluated for their preliminary in vitro anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv strain using broth dilution assay method. The results show that compounds 3a, 3c, 4a, 4b and 4h exhibited anti-tubercular activity at 25 ug/mL. Some of the selected compounds were evaluated for their preliminary in vitro antibacterial activity against Bacillus subtilis and Staphylococcus aureus and displayed mild antibacterial activity on comparison to standard streptomycin.