ABSTRACT

Varioııs substituted acetophenones (1-4) on treatment with iodine and thiourea yielded 2-amino-4-(substitııted-phenyl)-thiazole (la-4a), which on fıırther treatment with acetic anhydride generated N-(4-(substitutedphenyl)thiazol-2-yl)acetamide (lb-4b). İn another scheme, 3-(2-Aminothiazol-4-yl)phenol (la) reacted with various substituted aldehydes to get N-(substitutedbenzylidene)-4-(substitutedphenyl)thiazol-2-amine (lc-4c). Ali the synthesized compounds were characterized by their respective FT1R, ‘HNMR, Mass data and Elemental Analysis. Synthesized compounds (lb-4b, and lc-4c) ıvere subjected to investigation for their antimicrobial activities i. e. antibacterial and antifiıngal studies against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Asperigillus flavus and Asperigillus fumigatus by disk diffusion method. İn Scheme-1, compound 4b was found to be most effective with the largest zone of inhibition while in Scheme-2, compound 3c was found to be most effective against Staphylococcus aureus, Escherichia coli, Asperigillus flavus and Asperigillus fumigates. Compound lc was found to be most effective against Pseudomonas aeruginosa while Compounds lc and 3c both were found to be equally most effective against Candida albicans.