E-ISSN: 2148-6247
SYNTHESIS OF PLATINUM(II) COMPLEXES OF l-ARYL-3-(BENZIMIDAZOLE-2-YL)-PYRAZOLE-4-KETOXIMES AND STUDIES ON THEIR CYTOTOXIC EFFECTS
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Original Article
VOLUME: 5 ISSUE: 1
P: 45-52
April 2008

SYNTHESIS OF PLATINUM(II) COMPLEXES OF l-ARYL-3-(BENZIMIDAZOLE-2-YL)-PYRAZOLE-4-KETOXIMES AND STUDIES ON THEIR CYTOTOXIC EFFECTS

Turk J Pharm Sci 2008;5(1):45-52
Kadriye BENKLİ 1
İsmail KAYAGİL 1
Zerrin İNCESU-SELLER 2
Gühergül ULUÇAM 3
Şeref DEMİRAYAK 1
1. Anadolu University, Faculty Of Pharmacy, Department Of Pharmaceutical Chemistry, 26470, Eskisehir, Turkey
2. Anadolu University, Faculty Of Pharmacy, Department Of Biochemistry, 26470, Eskisehir, Turkey
3. Trakya University, Faculty Of Art And Science, Department Of Chemistry, 22030, Edime, Turkey
No information available.
No information available
Received Date: 14.11.2006
Accepted Date: 04.06.2007
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ABSTRACT

In this research, synthesis of some complexes in the presence of Pt(II) were studied. The structure of the compounds were elucidated by IR, 1H-NMR, Mass and Elemental Analyses. The cytotoxicity of Pt-complex was evaluated. The cellular responses through MTT method were measured in normal rat embryo fibroblast line F2408 and H-ras active-rat embryo fibroblast line 5RP7.

Keywords:
Metal complexes, ketoximes, MTT