ABSTRACT

Electrical energy offers numerous benefits for performing synthesis including increased reaction rates, yield enhancements, and cleaner chemistries. 2-N-phenylamino-5-(3,4-dichlorophenyl)-1,3,4- oxadiazoles were synthesized directly from the arylthiosemicarbazide at platinum electrode under controlled potential electrolysis in an undivided cell assembly in the acetonitrile. The synthesized compounds were screened for their in vitro growth inhibiting activity against different strains of bacteria and fungi viz., Klebsiella pneumoniae, Escherichia coli, Bacillus subtilis and Staphylococcus aureus and antifungal activity against Aspergillus niger, Crysosporium pannical, Pellicularia solmanicolor and Candida albicans and results have been compared with the standard antibacterial Penicillin and antifungal Dithane-M 45. Compounds 1a, d, g and j exhibited better while 1b, e, f and k slightly less antibacterial activity than standard Penicillin. Compounds 1a, d and j exhibited better while 1b, e, iandk displayed slightly less antifungal activity than standard Dithane-M 45.