ABSTRACT

In the present study, some hydrazone derivatives were synthesized via the reaction of 6-hydrazino-9-(P-D-ribofuranosyl)-9H-purine with various benzaldehydes. The structures of the compounds were elucidated by spectroscopic tecliniques such as H-NMR. 13C-NMR and ES-MS and elemental analyses. Anti-prolif-erative activity tests were perfonned on human lung (A549) and breast (MCF-7) cancer celi lines using MTT assay. Some derivatives were found to be effective against A549 and MCF-7 celi lines ainong these compounds. They exhibited time and dose dependent anti-proliferative activity against A549 and MCF-7 cancer celi lines.